Many patients starting antiviral therapy ask: can you take aciclovir on an empty stomach? The short answer is yes. Taking acyclovir with or without food is perfectly safe because there are no significant acyclovir food interactions. Does food affect aciclovir absorption? No, the medication will work just as effectively either way. However, if you are… Continue reading Can You Take Aciclovir on an Empty Stomach? Food Rules & Side Effects